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IGF-1 formerly called somatomedin, any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucoselevels.

IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. Blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.

IGF-1 exerts its effects via activation of the IGF-1 receptor. This receptor is widely distributed, which enables blood-transported IGF-1 to coordinate balanced growth among multiple tissues and organs. In contrast, autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independently of systemic GH. Examples of this type of growth regulation are wound healing and growth of the contralateral kidney after unilateral nephrectomy.

A test for IGF-1 can be used to help Evaluate pituitary function, Identify growth hormone (GH) deficiency; it is not diagnostic of a GH deficiency but may be ordered along with GH stimulation tests to offer additional information, also as follow-up to abnormal results on other hormone tests.

IGF-1 can be ordered with other pituitary hormone tests such as prolactin or FSH and LH, to help diagnose pituitary gland dysfunction and decreased pituitary hormones hypopituitarism.

IGF-1 is a hormone along with growth hormone, helps promote normal bone and tissue growth and development. IGF-1 test is often ordered along with GH. IGF-1 mirrors GH excesses and deficiencies, but the level in the blood is stable throughout the day, making it a useful indicator of average GH levels.