|Product name||Salbutamol Sulphate|
|CAS No.||51022-70-9||Outer Packing|
|Production date||12.26th., 2016||Shelf life||12.25th., 2019|
|Items of analysis||Specification||Results|
|Characteristics||White or almost white crystalline powder||Confirm|
|Identification||A: The UV absorption spectrum of the samples shows an absorption maximum at 276nm. The specific absorbance and the Maximum is 55 to 64. B: Chromatogram obtained with rest solution (b)is similar in position colour & size to the principal spot in the chromatogram obtained with the reference solution C: An orange-red color develop in methylene chloride layer.D: Infrared Absorption Spectrophotometry. E: It gives reaction (a) of sulphates||A.Positive absorbance is B.C.D.E.Positive|
|Solubility||Freely soluble in water, practically insoluble or very slightly soluble in alcohol & methylene chloride.||Complies|
|Appearance of solution||Solution S is clear and not more intensely coloured than reference solution in BY6.||Complies|
|Optical Rotation||-0.10゜~ +0.10゜determined on solution S||0.001゜|
|Acidity or alkalinity||NMT 0.4ml of 0.01M HCL||0.30ml|
|Single A,B,C,D,E,F,G,H,I impurities||≤0.3%||Complies|
|Loss on drying (w/w)||≤0.5%||0.15%|
|Assay||98.5% ~ 101.0%||99.62%|
Oral form – The usual dose of oral salbutamol is 2 to 4 mg three times a day in adult and 1 to 2 mg three times a day in children.
Inhaler formulation – One to two puffs (100 to 200 microgram) of salbutamol metered dose inhaler is inhaled as need basis, and one to two capsules (200 to 400 microgram) of salbutamol dry powder inhaler is inhaled as need basis.
Nebulizer solution – 1 to 2 ml of salbutamol nebulizer solution should be diluted with normal saline to final volume of 2-4 ml is inhaled from a nebulizer until aerosol generation ceases. It may be required repeated in severe acute attack.
Injection form – 5 to 10 ml (each ml contain 50 microgram) of salbutamol injection is used intramuscularly or intravenously in severe acute attack.
Albuterol Sulfate or Albuterol is also known as Salbutamol. Steroids Hormone Albuterol Sulfateis usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect of salbutamol can take place within five to 20 minutes of dosing, though some relief is immediately seen. It can also be given intravenously.Used in the treatment of bronchial asthma, asthmatic bronchitis, emphysema, patients bronchospasm.
Albuterol is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs.Albuterol inhalation is used to treat or prevent bronchospasm in people with reversible obstructive airway disease. It is also used to prevent exercise-induced bronchospasm.
Albuterol sulfate is a prescription medication indicated to treat or prevent airway constriction in people with asthma. This medication is a bronchodilator, which works by relaxing the bronchial muscles within a patient's airways to allow oxygen to reach the lungs. In certain instances, patients can develop allergic reaction symptoms after taking albuterol sulfate for the first time. Affected patients require immediate, emergency medical attention to avoid developing potentially life-threatening medical complications.