Alias: Cytomel T3 ; 3,3',5－triiodothyronine sodium
CAS NO: 55-06-1
Molecular formula: C15H11I3NNaO4
Nolecular weight: 672.96
Appearence: white to beige powder
Usage: Liothyronine Sodium is a synthetic variant of the human body's own thyroid hormone.
As a true hormone, T3 effects on target tissues are roughly four times more potent than those of T4. Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the liver and pituitary by removal of the iodine atom from the carbon atom number five of the outer ring of T4.
In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days. This compares with the half-life of T4, which is about 6.5 days.
L-Triiodothyronine(T3) and L-Thyroxine(T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. The pathway is part of a closed loop feedback process, elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system stabilizes the amount of thyroid hormones that are in the bloodstream.
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