Product :Nolvadex (Tamoxifen Citrate)
CAS No: 54965-24-1
MF: C26H29NO
MW: 371.51
Purity: 99%
Boiling point: 482.3°C at 760 mmHg
Storage: Sealed in the 2 ºC -8 ºC
Melting point:140-144 °C
flash point: 356.5ºC
Structure:
Einecs No: 234-118-0
Standard: Enterprise Standard
Other Anti Cancer Product: Tamoxifen Citrate, Clomiphene Citrate, Toremifene Citrate, Anastrozole, Raloxifene hydrochloride, Fulvestrant, Letrozole, Crotamiton
Usage:Tamoxifen is a female hormone which can blocks the actions of estrogen,it is usually used for treat some types of breast cancer in men and women.
Powder: per 1 gram of Tamoxifen Citrate
Produces: Highest concentration made - 20 mg/ml
Requirements:
1 gram of Tamoxifen Citrate
1 beaker suitable for holding the volume of liquids
19.6 ml of Glycerol
29.4 ml of 190 Proof Grain Alcohol
Powder: per 1 gram of Tamoxifen Citrate
Produces: Highest concentration made - 20 mg/ml
Requirements:
1 gram of Tamoxifen Citrate
1 beaker suitable for holding the volume of liquids
9.8 ml of PEG 600
39.2 ml of 190 Proof Grain Alcohol
Reduce breast cancer risk in women who haven't been diagnosed but are at higher-than-average risk for disease.
women and men diagnosed with advanced-stage or metastatic hormone-receptor-positive disease
women and men diagnosed with hormone-receptor-positive, early-stage breast cancer after surgery (or possibly chemotherapy and radiation) to reduce the risk of the cancer coming back (recurring)
Breast Cancer |
10 to 20 mg orally twice daily |
For metastatic breast cancer |
20 to 40 mg given in divided |
Women with Ductal Carcinoma |
20 mg daily for 5 years |
Reduce the incidence of breast cancer |
20mg daily for 5 years |
Node-positive breast cancer,axillary dissection |
10 mg orally 2 to 3 times daily for 5 years. |
Girls age 2 to 10 years with McCune-Albright Syndrome |
20 mg daily for one year |
1:Nolvadex Use in Cancer
Nolvadex |
Approved to prevent: Breast cancer in women who are at high risk for the disease. |
Breast cancer in women and men |
|
being studied in the treatment of other types of cancer. |
2:Benefits of Tamoxifen
A. Tamoxifen slows or stops the growth of cancer cells that are already present in the body. It helps keep the original breast cancer from coming back and helps prevent new cancer in the opposite breast. It also reduces the risk of breast cancer in women who have a high risk for this disease.
B. Tamoxifen is used to prevent and treat breast cancers that test positive for estrogen receptors (ER+). It blocks the effects that the hormone estrogen has on cancer cells and lowers the chance that breast cancer will grow. It is often called an "anti-estrogen."
C. Tamoxifen is highly effective in lowering the risk of breast cancer recurrence. In women who have already had breast cancer, tamoxifen also lowers the risk of breast cancer in the opposite breast (contralateral)
D. For postmenopausal women, a two-stage treatment using tamoxifen and then an aromatase inhibitor, such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) may work better than only taking tamoxifen.
Test Items |
Specification |
Test Results |
Description |
White crystalline powder |
White crystalline powder |
Identification |
IR , UV conform |
Conform |
Loss on drying |
≤0.5ml |
0.21ml |
Residue on ignition |
Not more than 0.2% |
0.06ml |
Iron |
Not more than 0.005% |
0.0018% |
Heavy metals |
Not more than 0.001% |
0.0006% |
Related substances |
Total: Not more than 1.0% Individual: Not more than 0.5% |
0.32% 0.14% |
E-isomer |
Not more than 0.3% |
0.19% |
Organic volatile impurities |
Conforms |
Conforms |
Assay |
99.0~101.0% |
99.51% |
Conclusion |
Conform with USP30 |