Liothyronine Sodium
Other name: L-Triiodothyronine(T3)
Alias:3,3',5-Triiodo-L-thyroninesodiumsalt,Sodium(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
CAS Registry Number: 55-06-1
Einecs No: 200-223-5
MF: C15H11I3NNaO4
MW: 672.96
Appearance: white or light yellow powder, almost tasteless.
Storage: Shading, confined preservation
Usage : It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate, such as, treatment of depressive disorders and use as a fat loss supplement
The usual starting dose of liothyronine for treating hypothyroidism is 5 to 25 mcg per day. The dose then is adjusted based on the patient's response and the blood levels of thyroid hormone. Optimal liothyronine doses are different for each patient and vary depending on the patient's age, weight, symptoms, blood levels of thyroid hormone and underlying conditions such as heart disease. Individuals who are hypothyroid will require thyroid hormone for life.
When T3 increases the rate of metabolism, it does the following:
Increase the amount of oxygen and energy used up by the body |
Increase the amount of calories required for normal body processes even when the muscles are rested |
Increase the population of sodium/potassium/ATPase, the primary energy-generating complex in the body |
Increase the use and breakdown of many nutrient macromolecules produced in the body |
T3 Brife Info:
As a thyroid hormone, T3, affects almost every physiological process in the body, including growth and development,metabolism, body temperature, and heart rate.
T3, regulates cellular growth rate, growth hormone production, the levels of nuclear T3 receptors via distinct dose response ranges in cultured GC cells.
Evidence for mediation by the nuclear T3 receptor, (T3) stimulates growth of cultured GC cells by action early in the G1 period.
Evidence for Cellular Binding Proteins and Conversion of T4 to T3, metabolism of L-Thyroxine (T4) and L-Triiodothyronine (T3) by Human Fibroblasts in Tissue Culture.
T3 COA:
Item |
Specification |
Result |
Appearance |
An odorless, almost white or buff colored powder |
pass |
Solubility |
1,Very slightly soluble in water |
pass |
2,slightly soluble in alcohol |
pass |
|
3,practically insoluble in most other organic solvents |
pass |
|
4,disolves in diluted aqueous sodium hydroxide solutions |
Pass |
|
Identificaton |
a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved. |
pass |
b)The retention time of the major peak is confirm to the RS |
pass |
|
Loss on Drying |
Not more than 4.0% |
0.46% |
[a]20/D |
+18 ~ +22o |
+20.9o |
Assay(HPLC) |
Not less than 95.0% |
99.18% |
Levothyroxine sodium |
Not more than 5.0% |
0.68% |
Conclusion: |
Up to the Standard for Export |