CAS : 112809-51-5
Synonyms:FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
Purity:99%
Appearance:White or light yellow crystal
Molecular Formula: C17H11N5
Molecular Weight: 285.31
Usage: Used as API in Treatment of breast disease.
Recommended dose of Femara is one 2.5 mg tablet administered once a day, without regard to meals.
Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.
Letrozole is used to treat breast cancer in postmenopausal women.
How to Store?
Out of reach of children
Keep it in the container tightly closed
Store it at room temperature and away from excess heat and moisture
Throw away any medication that is outdated or no longer needed
Letrozole lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Letrozole can stop or slow the growth of these cancers.
Letrozole only works in women who have had their menopause.
After the menopause, women don't produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormones called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Letrozole is a type of drug called an aromatase inhibitor. It blocks aromatase so that it can't change androgens into oestrogen.
200ml @ 5 mg/ml 1 gram of Letrozole powder 1 beaker suitable for holding the volume of liquids 19.9 ml of PEG 300 179.1 ml of 190 Proof Grain Alcohol |
Anti-estrogen Series |
|
Tamoxifen Citrate |
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Clomifene Citrate |
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Toremifene Citrate |
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Exemestane |
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Anastrozole |
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Letrozole |
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Fulvestrant |
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Common Side Effects:
Bone And Joint Pain
Fatigue
Dizziness
Drowsiness
Higher Cholesterol
Hot Flashes
Weight Gain
Nausea
Vomiting
Other Side Effects:
Swelling Of Hands, Feet, Ankles, Or Lower Legs
Loss Of Appetite
Constipation
Diarrhea
Difficulty Sleeping
Vaginal Bleeding
Breast Pain
Fever
Cough
Dry Skin
Rash
Letrozole Femara | ||
Tests | Specifications | Results |
Appearance | White or off-white crystaline powder |
White Crystalline powder |
Solubility
|
Soluble in Chloroform; Soluble in ethanol when heated |
Conform |
ldentification |
(1)Maximum absorption in wavelength of 240 nm Minimum absorption in wavelength of 215 nm |
Conform Conform |
(2)Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
Melting points | 182℃-184℃ | 182℃ |
Related substances | ≤0.5% | 0.3% |
Single impurity | ≤0.3% | 0.2% |
Loss on drying | ≤1.0% | 0.8% |
[Assay]C17H11N5 (On anhydrous basis) |
≥98.0% | 99.2% |
Conclusion | Conforms Specifications of Enterprise Standard. |