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|Product name:||Dextromethorphan Hydrobromide||Other Name:||Romilar|
|CAS :||125-69-9||Molecular formula:||C18H26BrNO|
|Molecular weight:||352.31||Appearance:||White Powder|
|Standard:||Enterprise Standard/ ISO9001|
pharma raw material,
Pharmaceutical Raw Materials
CAS No.: 125-69-9
EINECS No.: 204-750-1
Appearance: White or kind of white crystalline powder, soluble in water.
Generic Dextromethorphan syrup.
The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants.
A 2004 study showed that dextromethorphan was no more effective for children than a placebo.Studies conducted by the American Academy of Pediatrics show that dextromethorphan is not superior to a placebo in providing nocturnal symptom relief for children with cough and sleep difficulty due to upper respiratory infections.
A combination of dextromethorphan and quinidine, a CYP2D6 inhibitor, has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis.Dextromethorphan is also being investigated as a possible treatment for neuropathic pain and pain associated with fibromyalgia.In 2010, the FDA approved the combination product dextromethorphan/quinidine (Nuedexta) for the treatment of pseudobulbar affect (PBA)
DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.
|Test Items||Specification||Test Results|
|Appearance||white or almost white crystalline powder, slightly smelly||white crystalline powder|
|Residue On Ignition||Not more than 0.1%||Conforms|
|N.N - dimethylaniline||Comply with the standard||Conforms|
|Phenolic Compounds||Comply with the standard||Conforms|
|Related Substance||Comply with the standard||Conforms|
|Conclusion||This batch is complies with USP 34.|
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