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|Other Name:||Avodart||Type:||Hair Loss Treatment Powder|
|Melting Point::||42-250℃||Flash Point::||28.954°C|
pharma raw material
Alias: Avodart ; Duagen
CAS NO: 164656-23-9
Melting range: 246℃~248℃
Storage: -20°C Freezer
Appearance: white powder.
1, Used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
2, antihypertensive, ACE inhibitor
3, Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
Dutasteride (trademark name Avodart) is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). Used for benign prostatic hyperplasia; however, it increases the risk of erectile dysfunction and decreased sexual desire.
Dutasteride useful for the symptoms of benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate". In those who are being regularly screened 5-alpha-reductase inhibitor (finasteride and dutasteride) reduce the overall risk of being diagnosed with prostate cancer however there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases. This class of medications increases rates of erectile dysfunction (with between 5% and 9% developing problems after starting their use). This is linked to lower quality of life and can cause stress in relationships. There is also an association with lowered sexual desire. It has been reported that these adverse sexual side effects may persist even after discontinuation of the drug. The FDA has added a warning to dutasteride about an increased risk of high-grade prostate cancer. While the potential for positive, negative or neutral changes to the potential risk of developing prostate cancer with dutasteride has not been established, evidence has suggested it may temporarily reduce the growth and prevalence of benign prostate tumors, but could also mask the early detection of prostate cancer. The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia, which in turn could delay diagnosis and early treatment of the prostate cancer, thereby potentially increasing the risk of these patients developing high-grade prostate cancer.
1). Treating symptoms of benign prostatic hyperplasia (BPH) or enlargement of the prostate gland. It also helps to reduce the risk of urinary blockage and the need for surgery to treat BPH. It may be used alone or along with another medicine (tamsulosin).
Dutasteride is a 5 alpha-reductase enzyme inhibitor. It works by lowering levels of a hormone called dihydrotestosterone (DHT), which is a major cause of prostate growth. Lowering DHT leads to shrinkage of the enlarged prostate gland.
2). How to use Avodart?
A. At 2.5mgs/day is roughly 1.5x more effective than Finasteride at 5mgs/day,
B, At treating hair loss (both halting it as well as regrowing it).
In addition, Dutasteride can be used successfully at that same dose to treat prostate enlargement
3). Do NOT use Avodart if?
A. You are allergic to any ingredient in dutasteride or to another 5 alpha-reductase inhibitor (eg, finasteride)
B. The patient is a woman who is pregnant or may become pregnant
C. The patient is a child.
|Product name||Dutasteride (Avodart)|
|Appearance||White crystalline powder|
|Identification||By UV, To match with working standard||Complies|
|Related Substances||Not more than the reference solution (0.05%)||Complies|
|Loss on drying||＜0.5%||0.2%|
|Resiue on ignition||≤0.1%||0.05%|
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