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|Product name:||Clomifene Citrate||Other Name:||Serophene; Pergotime; Clomphid; Clomid|
|CAS register number:||50-41-9||Molecular formula:||C32H36ClNO8|
|Molecular weight:||598.08||Type:||Anti Estrogen Steroids|
|Usage:||Breast Cancer Treatment||Email:||Gavin@pharmrich.com|
1. What is clomifene citrate?
Clomifene citrate is a drug treatment that stimulates your ovaries to release eggs.
Ovulation stimulation using clomifene citrate is a well-established, effective treatment. Clomifene citrate is the most widely used of all fertility drugs.
Other drugs that may be used to treat ovulation disorders include metformin and bromocriptine.
2. What's the success rate of clomid?
About 70 per cent of women will ovulate in response to a fairly low dose of clomifene citrate. Of those who ovulate, about 40 per cent will become pregnant.
Other factors that can affect the pregnancy rate include:
the time in your cycle that you have sex
your age and weight
the count, shape, speed and motility (ability to move) of your partner's sperm
A low dose of clomifene may not be enough. Your doctor may increase the dose to help you conceive. Studies suggest that about 29 per cent of women who start taking the drug go on to have a live birth.
3. How does clomid work?
Clomifene citrate blocks the effect of the hormone oestrogen in your body. This blocking effect tricks your body into bumping up levels of two other hormones that are essential for ovulation. These two other hormones are:
1. follicle-stimulating hormone (FSH)
2. luteinising hormone (LH)
FSH causes the eggs in your ovaries to ripen, ready for release. LH triggers the release of one or more mature eggs from the ovary follicles. The egg or eggs then move down into one of your fallopian tubes.
4. How long will I have to take clomifene citrate for?
You usually take clomifene in pill form for five days early in your cycle, for up to six months at a time. A low dose of 50 mg is often used to start with.
1). If you have regular cycles, you'll start taking the pills within five days of your period starting, preferably on about day two.
2). If you're not menstruating at all or if your cycle is very irregular, your doctor will check that you're not pregnant. She'll then give you a synthetic version of the hormone progesterone, a progestogen called Provera.
3). Progesterone works with oestrogen to keep your reproductive cycle regular. Provera will re-establish your periods. Once you're having periods, you can then start taking clomifene citrate.
4). Ovulation generally occurs between five days and nine days after you've taken your last pill. Your fertility specialist may monitor your ovaries using ultrasound, at least during the first cycle. She'll look to see how your ovaries are responding and whether one egg follicle or more is preparing to release a mature egg into one of your fallopian tubes.
5). You might ovulate and conceive in the first month of taking clomifene citrate. Or it can take a month or two of drug therapy for you to start ovulating regularly.
6). Treatment may be continued for up to six cycles, as this is thought to be long enough to see whether your body is responding to the drug.
5. How to take clomid? effective cycle of clomid?
Clomid can be initiated at a dose of 50 mg daily for 5 days, starting on cycle day 3, 4, or 5 (where cycle day 1 is the first day of the menstrual period), thus being taken on cycle days 3-7, 4-8 or 5-9. During a clomifene-induced cycle, there should be frequent intercourse (every other day) the week before and including the estimated day of ovulation, (cycle days 9-18). If LH surge detection tests are used, these tests should be started 3 to 4 days after the last clomifene tablet is taken (that is, if taking clomifene on cycle days 4-8, LH surge tests should be started on cycle day 11) and continue until ovulation is indicated (that is, the test becomes positive.) or through cycle day 18. If there is no spontaneous surge, there may be an artificial triggering of oocyte release if there is an ovarian follicle of over 20 mm in size, such as by an intramuscular injection of 10,000 units of hCG.However, routinely using oocyte release triggering with HCG appears to decrease pregnancy chances compared to frequent monitoring with LH tests.
Clomid side effects for PCT cycle results:
Clomid tends to hold very little in the way of side effects for males, but there are a few notable Clomid side effects that will manifest themselves in the majority of users that every individual must be aware of. The majority of anabolic steroid users are males, and the majority of the typical Clomid side effects associated with female use of Clomid (for ovarian dysfunction in medicine) should never be seen in males. This is because men and women possess very different endocrine physiology, and any compounds or substances that have agonist/antagonist effects on sex hormones in the endocrine system will indeed exhibit very different effects between males and females. In the case of SERMs, the majority of men tolerate them quite well in comparison to females.
The typical potential Clomid side effects observed among female infertility patients are the following: abnormal bleeding from the uterus, headaches, vision problems, nausea and vomiting, abdominal cramps, vasomotor flushes, ovarian enlargement, OHSS (ovarian hyperstimulation syndrome), and possible long-term use of Clomid might result in ovarian tumor development.
Clomid Cycles & Doses
As Clomid side-effects are very rare and extremely mild if they occur at all, Clomid can be used for far extended periods of time if necessary; one could safely and effectively supplement with Clomid the entire duration of a cycle to prevent Gynecomastia if proven necessary. While Nolvadex is far more common to meet this end a simply dosing of 25mg of Clomid every day can in many cases be sufficient to prevent certain aromatase related side-effects while on cycle. However, many in the performance enhancing world will find this to be lacking as their doses of anabolic steroids will necessarily be high and stronger aromatase inhibitors will be needed.
Without question it is during the PCT period most will find Clomid to be the most beneficial and without question the most common time period in-which this SERM will be used. The majority of performance enhancers will find a 4 week total PCT period to be very efficient with 3 weeks of the total period consisting of Clomid. For example, a solid PCT schedule might include a 10-12 day period of hCG use followed by 3 weeks of Clomid therapy. Generally, a dosing of 150mg every day for one week followed by 2 weeks at 100mg can be very effective but depending on the individual some will need more time and another week or two at 50-100mg per day should suffice in this instance.
Contact Person: Gavin Lee